治疗白癜风的有效方法 http://www.baidianfeng51.cn/baidianfengzixun/wuliliaofa/294.html

PaperReading

01

ReversingSKI–SMAD4-mediatedsuppressionisessentialforTH17celldifferentiation

SongZhang,etal.

Nature,

Th17cellsarecriticallyinvolvedinhostdefence,inflammation,andautoimmunity.Inthispaper,theauthorsstudiedthemechanismsunderlyingtheimportantroleofTGFβsignalinginTh17celldifferentiation.TheyfoundthatSMAD4deletionledtoaTh17celldifferentiationintheabsenceofTGFβsignalling.Moreover,deletionofRORγtinSMAD4-deficientTcellsabolishedtheirTh17celldifferentiationintheabsenceofTGFβsignalling,whichsuggestedthatSMAD4inhibitedTh17celldifferentiationinaRORγt-dependentmanner.Mechanistically,SMAD4controlledTh17cellprogrambydirectlysuppressingRorcexpression.Inaddition,proteomicanalysisrevealedthatSMAD4interactswithSKI,atranscriptionalrepressorthatisdegradeduponTGFβstimulation.TheyfoundthattheSKI–SMAD4